Resources

Scientific Resources

Videos, application notes, publications, and posters — the scientific credibility hub for ORYL Photonics.

Videos

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Workflow

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

ORYL F1 is a plate-based solubility and aggregation profiling instrument powered by…

Technology

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

Most light-scattering workflows give you one readout. Ultrafast Light Scattering (ULS) gives…

Product Overview

ORYL F1 in 60 Seconds — High-Throughput Solubility & Aggregation Profiling

ORYL F1 is a high-throughput, low-compound, plate-based solubility and aggregation profiling instrument,…

Application Notes

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Formulation

AN-1002: DMSO QC

Compound management teams store large libraries as nominal 10 mM DMSO stocks, but not every…

Exploratory

AN-1004: Solubility LLS

Solubility remains a discovery bottleneck as hit lists expand, molecules become more complex, and early…

Discovery

AN-1001: H₂O/D₂O Calibration

Second Harmonic Scattering (SHS) is a novel technique for studying mechanisms of solubility, aggregation and…

Publications

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Peer-Reviewed

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Aqueous solubility is essential for drug absorption and bioavailability, but current assays face trade-offs between…

Peer-Reviewed

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

In this scientific article published in JPCB, we establish the experimental and theoretical foundation for…

Blog

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Blog

Two scattering signals. One measurement. Why that matters.

This post explains why we are positioning ORYL F1 around a category we call Ultrafast…

Blog

Stop inventing a new solubility workflow for every modality

Your small-molecule workflow wasn’t built for PROTACs. Your PROTAC workaround wasn’t built for peptides. And…

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Scientific Resources

Videos

ORYL F1 — Workflow Demo | Plate to Report in Under One Hour

ORYL F1 — How Ultrafast Light Scattering Works | SHS + LLS in One Measurement

ORYL F1 in 60 Seconds — High-Throughput Solubility & Aggregation Profiling

Application Notes

AN-1002: DMSO QC

AN-1004: Solubility LLS

AN-1001: H₂O/D₂O Calibration

Publications

High-throughput analysis of aqueous drug solubility, supersaturation, and aggregation behaviour using second harmonic light scattering

Solvent Redistribution Method To Determine Solubility and Aggregation: High Throughput, Accuracy, and Sustainability

Blog

Two scattering signals. One measurement. Why that matters.

Stop inventing a new solubility workflow for every modality

Need specific data for your application?

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