Applications

Browse Our Applications

From early discovery screening to formulation profiling, the ORYL F1 delivers decision-ready solubility and aggregation results across a wide range of applications — explore to see how the ORYL F1 can support your workflow.

Established

Fully validated, customer-anchored use-cases where the ORYL F1 is already delivering value in pharma R&D pipelines — see Application Notes for details.

Discovery

Compound DMSO Stock QC

Detect precipitation and degradation in your 10 mM DMSO compound library at plate scale — with no chemistry-specific reagents and no HPLC reference standards.

Discovery

Compound Characterization

Wide-range solubility characterization per compound, modality-agnostic at the framework level. Small molecules, peptides, PROTACs, MCPs, miniproteins — same workflow.

Discovery

Compound Triage

Bin compounds by solubility against your downstream assay window. Cut artifact-driven SPR re-runs and biochemical false positives, before they consume reagent and time.

In Development

Applications within the ORYL F1’s capabilities that we are actively developing — we’re always open to new partnerships, reach out if you see a fit.

Discovery

Protein-Protein Interaction

Detect dimer, tetramer, and higher-order assembly via complementary SHS and LLS readouts. Sensitive to interfaces and conformational ordering, not just mass.

Formulation

Vaccine Antigen Adsorption

Rank conditions for antigen-on-adjuvant adsorption efficiency, reading the adsorbed protein directly rather than inferring from supernatant depletion.

Discovery

Supersaturation Kinetics

Track precipitation kinetics from supersaturated states with fine temporal resolution. Lag phase, nucleation, growth — captured directly.

Discovery

Crystallization & Polymorph Screening

Monitor nucleation and crystal-form emergence directly via SHS. No transparency requirement on the matrix.

Formulation

Excipient Screening

Screen surfactants, sugars, amino acids, salts, and buffers for small molecule and biologic stabilization at plate scale — matrix sizes traditional methods choke on.

Formulation

High-Concentration Liquid Formulation

Aggregation propensity, viscosity proxies, and formulation ranking at concentrations where DLS saturates and B22 measurement is too slow to scale.

Application Notes

Detailed application data and workflows are available in our resource library.

Browse Application Notes

Have a specific application in mind?

Discuss your workflow with ORYL and see how the ORYL F1 can support your research.

Request a Demo

Browse Our Applications

Compound DMSO Stock QC

Compound Characterization

Compound Triage

Protein-Protein Interaction

Vaccine Antigen Adsorption

Supersaturation Kinetics

Crystallization & Polymorph Screening

Excipient Screening

High-Concentration Liquid Formulation

Application Notes

Have a specific application in mind?

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